Anti-CD20 monoclonal antibodies: reviewing a revolution
نویسندگان
چکیده
منابع مشابه
Monoclonal antibodies targeting CD20
We are commenting on the article by Klein et al. on the functional properties of several anti-CD20 monoclonal antibodies (mAbs) in the January/February 2013 issue of mAbs. 1 Rituximab, the first monoclonal antibody approved for cancer therapy, has truly revolutionized the treatment of a variety of CD20 + hema-tological malignancies, 2,3 and also has been studied in a large number of autoimmune ...
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Antibodies to CD20 have confirmed the hypothesis that monoclonal reagents can be given in vivo to alleviate human diseases. The targeting of CD20 on normal, malignant and auto-immune B-lymphocytes by rituximab has demonstrated substantial benefits for patients with a variety of B-cell lymphomas, as well as some with autoimmune disorders. There has been a notable increase in the survival rates f...
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CD19 is expressed on B- lineage cells and follicular dendritic cells and plays a key role in B cell malignancies and autoimmune diseases. Thus, it has been considered as potential target for several monoclonal antibodies (mAbs). For decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. But, anti- CD19 mAbs developed for treating...
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Ofatumumab, a novel humanized monoclonal anti-CD20 antibody, was recently approved by the FDA for the treatment of fludarabine and alemtuzumab refractory chronic lymphocytic leukemia (CLL). Ofatumumab effectively induces complement-dependent cytotoxicity (CDC) in vitro, and recent studies demonstrated that ofatumumab also effectively mediates antibody-dependent cellular cytotoxicity (ADCC). Pha...
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duced by the host. Also, one might introduce a gene for the immunizing portion of a disease-causing agent or vaccine into the chromosomes of the host in such a way that it is expressed at the time that vaccination would ordinarily take place. Such a gene would then become an inherited vaccine—each animal, in a sense, would have its own built-in vaccination shot—eliminating the need to vaccinate...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2018
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2018.1508624